This of course means it is time to speculate about the make-up of the teams for Game 1.
Latrell Mitchell's injury and unavailability mean Brad Fittler will be forced into making one large change to last year's victorious side. Will he go back to Clint Gutherson/Jack Wighton or blood a fresh talent?
Does Ryan Papenhuyzen finally make his Origin debut, or does someone else trump him for the utility spot?
All these questions will be answered over the coming weeks, however below are five players I genuinely consider 'Origin bolters'.
That is, players who probably weren't going to be considered in the pre-season but now could fly into selection contention.
5. Matt Burton
So of course I'm going to suggest running out a five-eighth as a centre.
That said, Burton is the reigning Dally M centre of the year. He was nothing short of incredible during his time out wide for the Panthers.
Prior to the injury to Mitchell, Burton was probably low down the pecking order given his early season form (or struggle to find it) but a move back to the centres makes the world of sense.
His utility value could see him picked in the 14 jersey off the bench. He covers a range of positions if anything goes wrong.
For mine, though he's within the top few options at centre.