Star Newcastle prop Daniel Saifiti could be forced to the sidelines for up to a month with injuries to his knee and foot.
The ailments, which precluded the 22-year-old from finishing the game against the Sharks, are believed to be minor strains to the MCL and mid-foot.
Newcastle head of physical performance Balin Cupples said Saifiti will miss a short period of time with the injuries.
"[Saifiti] caught some nasty friendly fire and got taken out lower body," Cupples told the club's website.
"He’s copped a minor grade MCL strain and a minor mid-foot strain as well.
The Knights will take on Penrith at home on Saturday.
Gold Coast will be without their preferred halves duo against Cronulla this weekend, as both Tyrone Roberts and Ash Taylor have been ruled out.
Roberts suffered an Achilles injury during the club's loss to Canberra on Sunday, and is set to be sidelined for the next 2-3 weeks with a strain to the injury.
Taylor will continue in his recovery from a quad injury, and is aiming at a round three return.
Finally, Melbourne will be without forward Tom Eisenhuth for an "indefinite period," after undergoing surgery on a fractured larynx.
Eisenhuth copped a stray elbow in the dying stages of the Storm's win over Brisbane on Thursday, but only just left hospital following an operation.
“We were all excited that Tom made his debut for Storm on Thursday, especially after such a long wait between NRL games since his debut in 2012, and it’s very unfortunate that he has suffered this setback,” Melbourne's General Manager – Football Frank Ponissi told the club's website.