The NRL's trial matches are officially underway, however, they have not come without injury setbacks to three stars of the league.

Penrith's Viliame Kikau was helped off the field in the opening minutes of his side's win over the Rabbitohs with a right knee injury.

It is understood that the Panthers forward suffered a grade one or two medial ligament issue, meaning he would be sidelined for two to six weeks.

At Shark Park, Manly's Tom Trbojevic went down in the first half with a hamstring complaint in his side's loss to Cronulla.

Sea Eagles coach Des Hasler confirmed the injury post-match and it is expected Trbojevic will miss around a month, placing him in doubt for round one.

Brisbane's Tevita Pangai Jnr is set to undergo scans on an injured hamstring after exiting the game in the first quarter in his side's win over the Wynnum Manly Seagulls.

it is concerning news for the Broncos powerhouse given his history of hamstring troubles.

“I am pretty disappointed. I worked hard on my hammies all pre-season so hopefully I am good for round one," Pangai told NRL Media.

“It is my right one. I felt a pop. I’ll get back on the horse and hopefully get my preparation right.

“It is early days and we’ve got a long season ahead. We’ve got a lot of depth as well. The young boys played well tonight and if I’m out I’m sure we’ll be covered.”