Tonga international Ata Hingano has had his season cut short, after suffering an ankle injury in the Pacific Test on Saturday night.
Hingano sustained a Syndesmosis injury, and will need surgery to repair the injury, which will rule him out of the remainder of the 2018 season.
The Bulldogs have also been dealt an injury blow following the representative round, with Kiwis forward Raymond Faitala-Mariner suffering a broken hand.
Faitala-Mariner was making his Test debut for New Zealand and will now be set for a stint on the sidelines in the Dogs' medical room.
Cronulla forward Wade Graham will miss the next three weeks after undergoing facial surgery to repair a fractured cheekbone.
Graham was hit in the head during the Sharks' clash with the Rabbitohs in round 13, before receiving another knock in round 15.
The forward had surgery to install a plate, and could potentially miss only one game given the Sharks have a bye in round 17.
"He's had the surgery and we're hoping he will just miss the one game," Sharks coach Shane Flanagan said.
"He's had the plate put in and he should be right to go for the Panthers in a couple weeks."