South Sydney's Adam Reynolds and Newcastle's Mitchell Pearce have both been ruled out of Origin I after the pair suffered injuries in round 11.
The injury curse is added to the absence of Luke Keary, who was ruled out with concussion on Friday night.
Reynolds could miss more than just the Origin opener, with what could be a fractured fibula.
The halfback will have scans on Sunday, with Wayne Bennett addressing the incident post-game.
"It's a lower leg injury, they're not sure what it is at the moment, it's somewhere around the calf area, there could be a fracture,'' Bennett told the media post-match.
"Who was to know if he was going to be picked or not [for NSW]. I'm feeling for South Sydney. We need him to play if we can, if he can't we'll get it done until he's back.
"He was playing great tonight and he's been very good every week. He's had injuries before in football. He's fine.''
Pearce will be joining Reynolds on the sidelines for Game One, with a groin strain ending his chances of selection.
Pearce was originally not in Origin contention, but has been one of the form players of the past month.
Despite now being unavailable for the series opener, Newcastle expect him to be fit for their next game, which comes against South Sydney on Friday week, with the Knights enjoying a bye next weekend.
And all of a sudden there goes nsw chances.
Now we will have to pick Cody walker at 6, who needs a dominant half to produce his best as shown by last nights game how quiet he was without Reynolds, and will he partnering an out of form down on confidence Cleary. And all of a sudden qld has a spine of Ponga/Munster/dce/hunt
Which will dominate
11.15 announced on the 9 footy show that Reynolds did not break his leg.
Qld at home by 20. I think Townsend should get picked in front of Cleary. 💪🐔👍
Adam Reynolds will be right for origin but i think they go Walker and Cleary. Which wouldn’t be the right call.
Souths on top softy. That’s all you need to worry about 🐰🐰🐰🐰🐰🐰
Look at redv13 hahaha you know that your team is trash, so you try bragging about a team you don’t even support. You’re are true fan
REDv13 is a Saint Illawarra Steeler N1TW1T…. now he follows Saint rabbit’0s 💩👃👅👅👅👅👅👅👅👅👅👅👅👅👅 Kev is going to be upset that you are’t brown nosing him but being a licckar to all soufffffffffffs fans 🤣😂🤣😂🤣😂🤣😂🤣😂🤣😂🤣😂🤣 what a mogot…..