Bulldogs v Roosters
The Bulldogs defeated the Cowboys on the weekend, and have come away from the clash with a clean bill of health.
As for the Roosters, forward Sio Siua Taukeiaho went down in the pre-game warm-up ahead of their loss to South Sydney last Thursday, and will miss the next two weeks with a knee injury.
Jared Waerea-Hargreaves will likely start at prop once again in Taukeiaho's place.
Warriors v Dragons
Leivaha Pulu will miss this clash after suffering a serious injury on the weekend, and while the Warriors haven't confirmed his recovery time, he certainly won't take the field this weekend.
Solomone Kata will likely miss the next month with an ankle injury, while injuries to Blake Ayshford, Nathaniel Roach and Gerard Beale mean the Warriors will have to stretch their depth to fill the left centre spot.
For the Dragons, Jame Graham didn't complete their win over the Sharks, although he is expected to take the field for this top four clash.
Broncos v Storm
Broncos prop Matt Lodge is in doubt for Friday's game against Melbourne, after suffering rib cartilage damage.
Lodge will be touch-and-go for the contest, with Brisbane hoping he will play despite having a light week on the training park.
Melbourne will welcome back Will Chambers from suspension, and he will replace Young Tonumaipea at right centre.
Rabbitohs v Raiders
Sam Burgess returns from suspension for the Bunnies, which will likely send Jason Clark to the bench and Kyle Turner out of the side.
Cameron Murray is a chance to play, as the Rabbitohs are hoping he has overcome his hamstring injury.
The Raiders are expected to be named 1-17 after beating Parramatta last weekend.
Wests Tigers v Knights
Chris Lawrence is expected to return from a hamstring injury for the Tigers.
Mitch Barnett returns from suspension for the Knights, which will likely push Jacob Saifiti out of the side.
Herman Ese'ese should also return to prop.
Cowboys v Titans
Matt Scott didn't finish North Queensland's loss to Canterbury last week due to a concussion injury, although he will line-up for Paul Green this weekend, who has flagged some potential changes given his side's poor start to the season.
For the Titans, Nathan Peats will likely miss this clash with a rib injury, which could see Mitch Rein start at hooker.
Ryan James and Morgan Boyle return, while Jai Arrow is also expected to play.
Eels v Sea Eagles
Jarryd Hayne is a chance of returning from injury, as Brad Arthur will likely stick to the same side from round six.
For the Sea Eagles, Jackson Hastings won't be named after causing some unrest among the playing group, although given he didn't play last weekend, there won't be much change this time around for Manly.
Sharks v Panthers
Andrew Fifita will likely be named despite suffering a knee injury last weekend, which the Sharks initially feared was a season-ending ACL injury.
However, Cronulla weren't as lucky with their other forwards, with Paul Gallen, Luke Lewis and Wade Graham all ruled out for this week's clash with Penrith.
In their place, Kurt Capewell will start, while Scott Sorensen, Jack Williams and James Segeyaro will all likely be named in the extended squad.
For Penrith, Josh Mansour will miss the next six weeks with a fractured cheekbone. Mansour joins Dallin Watene-Zelezniak, Waqa Blake and Tyrone Philips on the injury list for round seven.