Roosters vs Broncos
Sydney will be without hooker Jake Friend who has sustained a shoulder injury, although the Roosters hope he'll only miss two matches. Victor Radley looks set to shift back into hooker once again. Cooper Cronk is finally set to return, which will see Latrell Mitchell back out in his usual centre position.
Brisbane are set to welcome back Matt Lodge from suspension, which could see Tevita Pangai Jr return to a role off the bench.
Warriors vs Titans
Issac Luke will be touch and go after playing just 40 minutes against the Sea Eagles due to a hamstring issue. Nathaniel Roache will take his place if he doesn't prove his fitness.
For the Titans, they could welcome back their first-choice halves pairing, with Ashley Taylor and Tyrone Roberts both in line to return this weekend. Given they're both odds on to play, Ryley Jacks looks likely to drop out of the 17.
Panthers vs Wests Tigers
Viliame Kikau is closing in on a return from a knee injury, and has had Penrith's round four clash with Wests Tigers circled for a while. Despite struggling against Melbourne, the Panthers will keep Dylan Edwards at fullback on Friday night.
Benji Marshall's hamstring injury will see Josh Reynolds return to an NRL field, with his last game for the Tigers coming in Round 16, 2018.
Sea Eagles vs Rabbitohs
After recording a massive win over New Zealand, Des Hasler looks set to name the same 17 for this Saturday's clash with South Sydney.
For the Bunnies, Greg Inglis is 50/50, but should still be named after missing last weekend's win over the Titans. Braidon Burns' injury opens up a spot on the wing, with Jacob Gagan likely to fill the void. George Burgess returns from suspension to play his first game of the season.
Cowboys vs Raiders
Despite a big loss on the weekend, the Cowboys could go in 1-17 after they got through their clash with the Sharks unscathed.
Aidan Sezer will be a game-time decision after sustaining a side strain, although Sam Williams impressed during Sezer's absence which could make it a tough call for Ricky Stuart. Don't be surprised if Joseph Tapine returns from a broken thumb this weekend.
Eels vs Sharks
The Eels look set to remain unchanged, although Tepai Moeroa could return from a calf problem which could force a change from Brad Arthur.
Matt Moylan's injury could see Bronson Xerri play his first NRL game, with Josh Dugan to move to fullback to allow Xerri his preferred position at centre.
Storm vs Bulldogs
Both the Storm and Bulldogs are expected to name the same lineups that saw them record wins over the Panthers and Tigers respectively last weekend.
Knights vs Dragons
Kalyn Ponga will return to fullback with his experiment at five-eighth coming to an end. Connor Watson could return from injury and would slot into the halves if he passes the fitness test.
Gareth Widdop's injury means Matt Dufty could return to fullback, which could see Zac Lomax find himself back in the squad.