A host of players have been ruled out ahead of Round 13 and more are likely to follow as State of Origin wreaks havoc on club lineups.

Melbourne Storm vs Newcastle Knights

Melbourne Storm coach Craig Bellamy will let Cameron Smith, Cooper Cronk and Will Chambers make the final decision on whether they play against the Newcastle Knights.

Bellamy: "[Smith] pulled up worst of the three. Most of the say is up to them if theyโ€™re not injured. Thatโ€™ll be the case again."

Young hooker Brandon Smith has been named on the extended bench for the Storm and could make his debut for the club if Cameron Smith doesn't play or if Bellamy decides to not use him for the full 80 minutes.

The Knights look to be unchanged from the team named earlier in the week.

Parramatta Eels vs New Zealand Warriors

Parramatta have ruled out forwards Tim Mannah and Siosaia Vave from the squad named earlier in the week, with Mannah (ribs) and Vave (calf) succumbing to injury.

Jacob Lillyman is said to be right to go after playing Origin on Wednesday.

St George Illawarra Dragons vs Wests Tigers

Gareth Widdop is still a chance to play this weekend, while Josh Dugan looks to have made it through Origin without injury and is set to take his place in the lineup, as is Tyson Frizell.

No late changes expected for the Wests Tigers with the club having no concerns for their Origin duo, while Tuimoala Lolohea will make his debut for the club.

Sydney Roosters vs Brisbane Broncos

The Roosters have lost halfback Mitchell Pearce to aย concussion for their match against the Brisbane Broncos.

"The doctor assessed him last night and he won't be playing. He'll have to go through the concussion protocol but the symptoms are there," Roosters coach Trent Robinson said on Friday.

Dylan Napa left the field during Origin with a leg injury but returned later in the match and is expected to play, as is Aidan Guerra and Blake Ferguson.

The Brisbane Broncos will also be without their State of Origin half with Anthony Milford also being ruled out with a concussion. To make matters worse the Broncos, Kodi Nikorima has succumbed to a shoulder injury as well.

Benji Marshall will start for Milford, whileย Jaydn Suโ€™A will replace Nikorima on the bench.

North Queensland Cowboys vs Gold Coast Titans

North Queensland coach Paul Green has confirmed that centre Justin O'Neill will miss the clash with Gold Coast after being concussed in the second half at Suncorp Stadium.

Michael Morgan is expected to play with Javid Bowen likely to replace O'Neill.

Nathan Peats is also listed as "highly unlikely" to play against the Cowboys after suffering a cork, while Blues teammateย Jarryd Hayne will take his place after a light run on Friday morning.

Karl Lawton is expected to start in place of Peats.

Manly Sea Eagles vs Canberra Raiders

Nate Myles has all but been ruled out of Sunday's NRL match against Canberra after scans on Thursday confirmed the Maroons veteran had torn a ligament in his elbow. In good news for the Sea Eagles,ย Jake Trbojevic is set to play.

Josh Papalii is also expected to play for the Raiders, with no concerns following Wednesday's match.

Canterbury-Bankstown Bulldogs vs Penrith Panthers

The Bulldogs look to have come through Origin unscathed with Josh Jackson, David Klemmer and Brett Morris all expected to play.

 

The Panthers didn't have anyone playing Origin but will field a vastly different team this week with Matt Moylan shifting to five-eighth and Mitch Rein making his debut for the club at hooker.