The Knights have named Mitchell Pearce and David Klemmer's replacements for Saturday's clash with the Warriors at McDonald Jones Stadium.
Following the duo's call up to the NSW Origin camp, Newcastle were granted permission to add halfback Phoenix Crossland and front rower Jirah Momoisea to the team list.
Crossland, a NSW representative halfback, comes through the club's elite academy and was recently promoted to the club's top 30.
Momoisea joined the fulltime squad on a development deal ahead of the June 30 deadline.
Jamie Buhrer and Shaun Kenny-Dowall will captain the side.
Knights line-up for Round 16
1. Connor Watson
2. Hymel Hunt
3. Kurt Mann
4. Jesse Ramien
5. Shaun Kenny-Dowall
6. Mason Lino
14. Jamie Buhrer
8. James Gavet
9. Danny Levi
10. Jacob Saifiti
11. Lachlan Fitzgibbon
12. Sione Mata'utia
15. Herman Ese'ese
Interchange
16. Josh King
17. Pasami Saulo
18. Aidan Guerra
19. Brodie Jones
20. Tex Hoy
21. Tautau Moga
22. Jirah Momoisea
23. Phoenix Crossland