NEWCASTLE, AUSTRALIA - MARCH 11: Jarryd Hayne of the Titans leaves the ground after sustaining an injury during the round two NRL match between the Newcastle Knights and the Gold Coast Titans at McDonald Jones Stadium on March 11, 2017 in Newcastle, Australia. (Photo by Tony Feder/Getty Images)

The Gold Coast Titans look set to be without star fullback Jarryd Hayne for a while after he suffered a serious ankle injury in their loss to the Newcastle Knights.

Hayne wasn't the only casualty, though, with Anthony Don and Karl Lawton also be forced from their field with suspected shoulder dislocations.

The Titans are already without Nathan Peats (shoulder), Pat Politoni (arm) and John Olive (pec).

"We're not real good… we've got two with dislocated shoulders and quite a serious ankle injury," Titans coach Neil Henry said post-match.

"I don't know any prognosis but you can safely say none of those three will play next week, and it could be a lot longer, we will just wait and see.

"Jarryd's hurt his ankle quite bad, there's a lot of swelling there so we will have to wait until we get a bit of a scan and see what's happened.

"Going for that kick he sort of got blocked and got his foot trapped.

"It was just a freak thing, it was a nicely-weighted kick and got a result out of it in the end so yeah, frustrating for everyone concerned, particularly him.

"The medical team have had a look and we will know a bit more in a day or two."