The Sea Eagles are the form team in the competition at this stage of the season and have won their past five to surge into third spot on the table.
They'll lose Jake Trbojevic to Origin 3 but will gain Daly Cherry-Evans, after many thought the halfback was a chance to replace JT in the Maroons' line-up for the decider.
For Penrith, they've lost their past two matches and have lost grip on eighth spot, a position they held just three weeks ago.
Tyrone Peachey replaces Dean Whare at centre, while Mitch Rein returns to his place at hooker, with Sione Katoa dropping to the bench.
Manly should continue on their winning ways in this one, although it won't be easy.
Sea Eagles by 2.
All Run Metres0