A knee injury to Nathan Cleary has further soured a disappointing 20-18 defeat for the Panthers against the Bulldogs at ANZ Stadium on Friday.

Cleary did not return to the field after halftime and sat with ice strapped to his knee.

Early reports suggest a medial ligament injury which could see the 20-year-old sidelined somewhere between one to four weeks.

Cleary will now go for scans to confirm the extent of the injury.

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