MUDGEE, AUSTRALIA - APRIL 17: Tom Trbojevic of the Sea Eagles scores a try during the round six NRL match between the Manly Sea Eagles and the Gold Coast Titans at Glen Willow Sporting Complex, on April 17, 2021, in Mudgee, Australia. (Photo by Mark Metcalfe/Getty Images)

Manly superstar Tom Trbojevic is set to be rested for the Sea Eagles' clash with St George Illawarra on Friday.

The decision, first reported by AAP's Scott Bailey, comes from coach Des Hasler as Trbojevic looks for rest following Origin duties.

The ace fullback has been sensational for the Blues in clinching the 2021 series in the opening two fixtures, and will be in strong contention to take home the Wally Lewis Medal.

Trbojevic, who has flourished in the centres along with Rabbitohs fullback Latrell Mitchell for NSW, has been a key barometer for Manly in 2021.

The 24-year-old has been limited to just the nine matches for the season due to an off-season hamstring issue, but has claimed a record of 7-2 when featuring for the Sea Eagles this year.

Trbojevic's injury history is a likely factor for Hasler to rest his star man, but Manly will hope their fortunes without their gun No.1 turn, managing just two wins in their six games without him.

NEWCASTLE, AUSTRALIA - APRIL 13: Tom Trbojevic of the Manly Sea Eagles in the warm up during the round five NRL match between the Newcastle Knights and the Manly Sea Eagles at McDonald Jones Stadium on April 13, 2019 in Newcastle, Australia. (Photo by Tony Feder/Getty Images)

The Sea Eagles will enter Friday's clash as clear favourites however, with the Dragons' recent COVID-19 player reach taking it's toll on Anthony Griffin's selection flexibility.

The NRL handed suspensions to all 12 players involved in the breach, with those suspensions able to be spread out across the next month.