The Newcastle Knights will be scrambling to field a team this week after confirming a number of injuries from the weekend.
Pearce has sustained a ruptured pectoral which will require surgery and is facing 10-12 weeks on the sidelines.
Fill-in fullback Hoy suffered a hamstring strain and is likely to be sidelined between two to four weeks.
While Mann left the field early in the second half for a HIA assessment and has since failed which will see him miss the Knights next match.
Young centre Dominic Young is another loss from the weekend after suffering a knee injury in the first half of the Knights NSW Cup match.
He’s awaiting further opinion specialists before knowing when his return to play will be.
The Knights Round 5 match is against the Gold Coast Titans at Cbus Super Stadium on Saturday afternoon.